In this article, I cast doubt on an apparent truism, namely, that if evidence is available for gathering and use at a negligible cost, then it’s always instrumentally rational for us to gather that evidence and use it for making decisions. Call this ‘value of information’ (VOI). I show that VOI conflicts with two other plausible theses. The first is the view that an agent’s evidence can entail non-trivial propositions about the external world. The second is the view that epistemic (...) rationality requires us to update our credences by conditionalization. These two theses, given some plausible assumptions, make room for rationally biased inquiries where VOI fails. I go on to argue that this is bad news for defenders of VOI. (shrink)

In this paper, we present a bibliometric analysis of the Periodic Table. We have conducted a comprehensive analysis of Scopus based database using the keyword “Mendeleev Periodic Table". Our findings suggest that the Periodic Table is an influential topic in the field of Inorganic as well as Organic Chemistry. Areas for future research could include on expanding our analysis to include other bibliometric indicators to gain a more comprehensive understanding of the impact of the Periodic Table in the chemistry-based scientific (...) investigations and even in the field of astrochemistry, which explores chemical processes in space, is intricately linked to fundamental chemistry. In this context, the quote of Carl Sagan is relevant where he eloquently expressed an inherent connection between chemistry and astrophysics: “The nitrogen in our DNA, the calcium in our teeth, the iron in our blood, the carbon in our apple pies were made in the interiors of collapsing stars.” In the ongoing study we have presented a ground level investigation of the conjecture of Sagan via Periodic Table based on bibliometric analysis whereas in the next level our aim is to present the stellar connection of it through Hertzsprung-Russel diagram as well as cluster of stars. The Periodic Table holistically serves as a foundational platform for understanding chemical elements both on the Earth and in celestial bodies. The present investigation fundamentally identifies the main working field of research and lays the groundwork for potential connections to astrochemical studies. (shrink)

According to Bayesian orthodoxy, an agent should update---or at least should plan to update---her credences by conditionalization. Some have defended this claim by means of a diachronic Dutch book argument. They say: an agent who does not plan to update her credences by conditionalization is vulnerable (by her own lights) to a diachronic Dutch book, i.e., a sequence of bets which, when accepted, guarantee loss of utility. Here, I show that this argument is in tension with evidence externalism, i.e., the (...) view that an agent's evidence can entail non-trivial propositions about the external world. I argue that this tension casts doubt on the idea that diachronic Dutch books can be used to justify or vindicate updating plans. (shrink)

Textures of the Ordinary shows how anthropology finds a companionship with philosophy in the exploration of everyday life. Based on two decades of ethnographic work among low-income urban families in India, Das shows how the notion of texture aligns ethnography with the anthropological tone in Wittgenstein and Cavell, as well as in literary texts. The book shows different routes of return to the everyday as it is corroded not only by catastrophic events but also by repetitive and routine violence within (...) everyday life itself. As an alternative to normative ethics, this book develops ordinary ethics as attentiveness to the other and as the ability of small acts of care to stand up to horrific violence. Textures of the Ordinary offers a model of thinking in which concepts and experience are shown to be mutually vulnerable. The book is an intellectually intimate invitation into the ordinary, that which is most simple yet most difficult to perceive in our lives. (shrink)

Trata-se aqui de interpretar algumas passagens do Cândido no quadro das linhas de força do iluminismo francês, que dizem respeito ao modo de conceber a atividade do filósofo, orientado pela oposição entre as figuras do "filósofo de gabinete" e o "filósofo mundano." Do meu ponto de vista, esta oposição não encerra tão somente uma tomada de posição sobre a natureza da ação do filósofo, mas diz respeito mesmo a uma concepção do que é a "boa filosofia." Ao mesmo tempo, permitirá (...) uma interpretação da famosa metáfora do jardim do final do Cândido à luz da concepção voltaireana da história. (shrink)

This essay explores a problem for Nyāya epistemologists. It concerns the notion of pramā. Roughly speaking, a pramā is a conscious mental event of knowledge-acquisition, i.e., a conscious experience or thought in undergoing which an agent learns or comes to know something. Call any event of this sort a knowledge-event. The problem is this. On the one hand, many Naiyāyikas accept what I will call the Nyāya Definition of Knowledge, the view that a conscious experience or thought is a knowledge-event (...) just in case it is true and non-recollective. On the other hand, they are also committed to what I shall call Nyāya Infallibilism, the thesis that every knowledge-event is produced by causes that couldn’t have given rise to an error. These two commitments seem to conflict with each other in cases of epistemic luck, i.e., cases where an agent arrives a true judgement accidentally or as a matter of luck. While the Nyāya Definition of Knowledge seems to predict that these judgements are knowledge-events, Nyāya Infallibilism seems to entail that they aren’t. In this essay, I show that Gaṅgeśa Upādhyāya, the 14th century Naiyāyika, solves this problem by adopting what I call epistemic localism, the view that upstream causal factors play no epistemically significant role in the production of knowledge. (shrink)

This paper is about a tension between two theses. The first is Value of Evidence: roughly, the thesis that it is always rational for an agent to gather and use cost‐free evidence for making decisions. The second is Rationality of Imprecision: the thesis that an agent can be rationally required to adopt doxastic states that are imprecise, i.e., not representable by a single credence function. While others have noticed this tension, I offer a new diagnosis of it. I show that (...) it arises when an agent with an imprecise doxastic state engages in an unreflective inquiry, an inquiry where they revise their beliefs using an updating rule that doesn't satisfy a weak reflection principle. In such an unreflective inquiry, certain synchronic norms of instrumental rationality can make it instrumentally irrational for an agent to gather and use cost‐free evidence. I then go on to propose a diachronic norm of instrumental rationality that preserves Value of Evidence in unreflective inquiries. This, I suggest, may help us reconcile this thesis with Rationality of Imprecision. (shrink)

Recently, several epistemologists have defended an attractive principle of epistemic rationality, which we shall call Ur-Prior Conditionalization. In this essay, I ask whether we can justify this principle by appealing to the epistemic goal of accuracy. I argue that any such accuracy-based argument will be in tension with Evidence Externalism, i.e., the view that agent's evidence may entail non-trivial propositions about the external world. This is because any such argument will crucially require the assumption that, independently of all empirical evidence, (...) it is rational for an agent to be certain that her evidence will always include truths, and that she will always have perfect introspective access to her own evidence. This assumption is in tension with Evidence Externalism. I go on to suggest that even if we don't accept Evidence Externalism, the prospects for any accuracy-based justification for Ur-Prior Conditionalization are bleak. (shrink)

This first full-length study of the Arabic reception of Plato's Timaeus considers the role of Galen of Pergamum in shaping medieval perceptions of the text as transgressing disciplinary norms. It argues that Galen appealed to the entangled cosmological scheme of the dialogue, where different relations connect the body, soul, and cosmos, to expand the boundaries of medicine in his pursuit for epistemic authority – the right to define and explain natural reality. Aileen Das situates Galen's work on disciplinary boundaries in (...) the context of medicine's ancient rivalry with philosophy, whose professionals were long seen as superior knowers of the cosmos vis-à-vis doctors. Her case studies show how Galen and four of the most important Christian, Muslim, and Jewish thinkers in the Arabic Middle Ages creatively interpreted key doctrines from the Timaeus to reimagine medicine and philosophy as well as their own intellectual identities. (shrink)

In Sanskrit philosophy, the closest analogue of intuition is pratibhā. Here, I will focus on the theory of pratibhā offered by the Sanskrit grammarian Bhartṛhari (fifth century CE). On this account, states of pratibhā play two distinct psychological roles. First, they serve as sources of linguistic understanding. They are the states by means of which linguistically competent agents effortlessly understand the meaning of novel sentences. Second, states of pratibhā serve as sources of practical knowledge. On the basis of such states, (...) both human and non-human agents unreflectively know which actions they should perform under which circumstances. Given these two roles of pratibhā, modern commentators have often claimed that states of pratibhā, as understood by Bhartṛhari, are intuitions. In this article, I will reconstruct Bhartṛhari's view and to explore its consequences, I will argue that, if Bhartṛhari’s theory of pratibhā is right, then a form of human exceptionalism – which makes rationality a unique trait of human beings – becomes difficult to maintain. (shrink)

We read with interest Dominic Wilkinson’s article “Frailty Triage: Is Rationing Intensive Medical Treatment on the Grounds of Frailty Ethical?” on the utility of the Clinical Frailty Score in...

Volume 19, Issue 6, June 2019, Page 34-36.

In this essay, my aim is to explain Vātsyāyana’s solution to a problem that arises for his theory of liberation. For him and most Nyāya philosophers after him, liberation consists in the absolute cessation of pain. Since this requires freedom from embodied existence, it also results in the absolute cessation of pleasure. How, then, can agents like us be rationally motivated to seek liberation? Vātsyāyana’s solution depends on what I will call the Pain Principle, i.e., the principle that we should (...) treat all aspects of our embodied existence as pain. If we were to follow this advice, we would come to apply the label of pain to all aspects of our embodied existence, including pleasure. This would undermine our attachment to our own embodied existence. I show that this fits with Vātsyāyana’s general theory of motivation. According to this theory, by manipulating the labels using which we think about the world and ourselves, we can induce radical shifts in our patterns of motivation. (shrink)

As Alfandre and colleagues describe in “Between Usual and Crisis Phases of a Public Health Emergency: The Mediating Role of Contingency Measures”, efforts to maintain standards of care durin...

Saitya Brata Das rigorously examines Schelling's theologico-political works and sets his thought against his more dominant contemporary, Hegel. Das argues that Schelling inaugurates a new thinking outside of Occidental metaphysics, by a paradoxical manner of exit, which prepares for the post-metaphysical philosophy of Martin Heidegger, Franz Rosenzweig and Jacques Derrida. This new reflection, outside of the Universal world-historical politics of modernity, is achieved by re-thinking religion as eschatology. Intervening in contemporary debates on post-secularism and the return to religion, Das shows (...) that religion, in an essential sense, always opens up infinitude from the heart of finitude, to an irreducible outside of the profane order of worldly hegemonies. Religion here assumes a negative political theology of exception without sovereign power. (shrink)

In classical South Asia, most philosophers thought that the self (if it exists at all) is what the first-person pronoun ‘I’ stands for. It is something that persists through time, undergoes conscious thoughts and experiences, and exercises control over actions. The Buddhists accepted the ‘no self’ thesis: they denied that such a self is substantially real. This gave rise to a puzzle for these Buddhists. If there is nothing substantially real that ‘I’ stands for, what are we talking about when (...) we speak of ourselves? In this paper, I present one Buddhist answer to this question, an answer that emerges from the work of the Abhidharma thinker Vasubandhu (4th to 5th century CE). (shrink)

This article uses critical discourse analysis to examine how the higher COVID-19 infection rates among South Asians in general, and Punjabis more specifically, have been represented by conservative politicians and their representatives as a consequence of cultural and religious practices. Two counter-narratives are discussed. The first substitutes the negative image of the Sikh Punjabi Canadian community with a celebratory and positive view of Sikh humanitarianism and community service. The second attributes the high numbers to class attributes such as precarious jobs, (...) poverty-level wages, employment insecurity, lack of sick days, over-crowded housing, racism and lack of access to healthcare. We argue that the conservative explanation as well as the first counter-narrative reveal continuities in culturalist understandings of South Asian immigrants, albeit in slightly different ways. The second counter-narrative represents a discursive resistance by advancing a structural analysis of health and disease in immigrant communities. (shrink)

In A Confection of Refutation (Khaṇḍanakhaṇḍakhādya), the twelfth-century philosopher and poet Śrīharṣa addresses a version of Meno’s paradox. This version of the paradox was well known in first millennium South Asia through the writings of two earlier Sanskrit philosophers, Śabarasvāmin (4th–5th century ce) and Śaṃkara (8th century ce). Both these thinkers proposed a solution to the paradox. I show how Śrīharṣa rejects this solution, and splits the old paradox into two new ones: the paradox of triviality and the paradox of (...) incoherence. I argue that these paradoxes are connected to Śrīharṣa’s broader pessimism about the possibility of successful rational inquiry into certain philosophical questions. (shrink)

In this paper I evaluate some recent virtue-ethical accounts of right action [Hursthouse 1999; Slote 2001; Swanton 2001]. I argue that all are vulnerable to what I call the insularity objection : evaluating action requires attention to worldly consequences external to the agent, whereas virtue ethics is primarily concerned with evaluating an agent's inner states. More specifically, I argue that insofar as these accounts are successful in meeting the insularity objection they invite the circularity objection : they end up relying (...) upon putatively virtue-ethical considerations that themselves depend on unexplained judgments of rightness. Such accounts thus face a dilemma that is characteristic of virtue-ethical accounts of right action. They avoid the insularity objection only at the cost of inviting the circularity objection: they become intuitively plausible roughly to the extent that they lose their distinctively virtue-ethical character. (shrink)

Saitya Brata Das argues that in Kierkegaard's work we find a radical eschatological critique, not only of the liberal-humanist pathos of modernity but also the political theology of Carl Schmitt, that seeks to legitimise the sovereign power of the state by an appeal to a divine or theological foundation. Relating Kierkegaard's notion of 'Christianity without Christendom' to the Schellingian eschatological critique of sovereignty, he shows how Schelling's insistence on the eschatological difference between religion and politics is transformed and further intensified (...) in Kierkegaard's critique of historical reason. Such an exception without sovereignty, Das argues, is the very task of our contemporary time. (shrink)

An important question in epistemology is whether the KK principle is true, i.e., whether an agent who knows that p is also thereby in a position to know that she knows that p. We explain how a “transparency” account of self-knowledge, which maintains that we learn about our attitudes towards a proposition by reflecting not on ourselves but rather on that very proposition, supports an affirmative answer. In particular, we show that such an account allows us to reconcile a version (...) of the KK principle with an “externalist” or “reliabilist” conception of knowledge commonly thought to make that principle particularly problematic. (shrink)

The guiding inspiration of this book is the attraction and distance that mark the relation between anthropology and philosophy. This theme is explored through encounters between individual anthropologists and particular regions of philosophy. Several of the most basic concepts of the discipline—including notions of ethics, politics, temporality, self and other, and the nature of human life—are products of a dialogue, both implicit and explicit, between anthropology and philosophy. These philosophical undercurrents in anthropology also speak to the question of what it (...) is to experience our being in a world marked by radical difference and otherness. In The Ground Between, twelve leading anthropologists offer intimate reflections on the influence of particular philosophers on their way of seeing the world, and on what ethnography has taught them about philosophy. Ethnographies of the mundane and the everyday raise fundamental issues that the contributors grapple with in both their lives and their thinking. With directness and honesty, they relate particular philosophers to matters such as how to respond to the suffering of the other, how concepts arise in the give and take of everyday life, and how to be attuned to the world through the senses. Their essays challenge the idea that philosophy is solely the province of professional philosophers, and suggest that certain modalities of being in the world might be construed as ways of doing philosophy. Contributors. João Biehl, Steven C. Caton, Vincent Crapanzano, Veena Das, Didier Fassin, Michael M. J. Fischer, Ghassan Hage, Clara Han, Michael Jackson, Arthur Kleinman, Michael Puett, Bhrigupati Singh. (shrink)

The use of single-use items is now ubiquitous in medical practice. Because of the high costs of these items, the practice of reusing them after sterilisation is also widespread especially in resource-poor economies. However, the ethics of reusing disposable items remain unclear. There are several analogous conditions, which could shed light on the ethics of reuse of disposables. These include the use of restored kidney transplantation and the use of generic drugs etc. The ethical issues include the question of patient (...) safety and the possibility of infection. It is also important to understand the role of informed consent before reuse of disposables. The widespread practice of reuse may bring down high healthcare costs and also reduce the huge amount of hospital waste that is generated. The reuse of disposables can be justified on various grounds including the safety and the cost effectiveness of this practice. (shrink)

The search for definitions is ubiquitous in Sanskrit philosophy. In many texts across traditions, we find philosophers presenting their theories by laying down definitions of key theoretical categories, by testing those definitions, and by refuting competing definitions of the same theoretical categories. Call this the method of definitions. The aim of this essay is to explore a challenge that arises for this method: the paradox of definitions. It arises from the claim that the method of definitions is either (i) redundant (...) because it does not provide us any knowledge that we did not already possess, or (ii) impossible to successfully pursue because it leads to an infinite regress. Neither of these alternatives should be acceptable to the defender of this method. To focus our discussion, I will show how this challenge arose for—and was arguably resolved by—early Nyāya-Vaiśeṣika thinkers active in the first millennium CE and at the very beginning of the second millennium. In response to the paradox of definitions, these Nyāya-Vaiśeṣika thinkers claimed that the purpose of a definition is to remove either metaphysical ignorance about the distinction between theoretically significant kinds or kind-membership, or metalinguistic ignorance about the meaning or the application-conditions of theoretically significant terms. I will show how this discussion helps us to ward off certain misconceptions about the method of definitions in Nyāya-Vaiśeṣika. (shrink)

Given many meanings that the school has adopted for each person, we have found the need to provide some reflections on the subject, supported in a philosophical perspective, in order to enlarge the debate on the values of the school for teachers and students, especially. This brief paper aims to make a cut about the value that the figure of the object "school" has adopted for teachers and students. We refer to the school, involving only the institutions of the levels (...) from elementary to secondary school, not including the institutes or other levels. The work has as scientific foundations philosophical contributions of authors like Herbart, Wittgenstein, MacIntyre, Deleuze, Aristotle, Dewey, Foucault, and orientations coming from the linguistics of Saussure, which supports us in the understanding and management of language. (shrink)

Cultural diversity is an inescapable reality and a concern in many businesses where it can often raise ethical questions and dilemmas. This paper aims to offer suggestions to certain problems facing managers in dealing with cultural diversity through the inspiration of Thomas Aquinas. Although he may be perceived as a voice from the distant past, we can still find in his writings helpful and original ideas and criteria. He welcomes cultural differences as a part of the perfection of the universe. (...) His systemic approach leads one to place the problem in its proper context, and to reflect on it from the perspective of virtue ethics, with a central role for practical wisdom and giving primacy to neighborly love and natural moral law. Rather than a set of rigid standards with no consideration of diversity Aquinas focuses on the common human ground, which allows for the indispensable dialogue between different positions. When dealing with practical questions, the problem is one of finding the right balance between general principle and cultural specifics, tolerance, and dialogue, always guided by practical wisdom. In this way, Aquinas’ approach is neither rigid ethical universalism with no consideration for diversity nor moral relativism with no place for any transcultural and absolute morals. (shrink)

Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the cartilage surface as well as controlling adhesion‐dependent synovial growth and regulating bulk protein deposition onto the cartilage. However, recent evidence suggests that it can bind to and effect downstream signaling of a number of cell surface receptors implicated in regulating the inflammatory response. Therefore, we pose the hypothesis: Does PRG4 regulate the inflammatory response and maintain tissue homeostasis? (...) Based on these novel findings implicating PRG4 as an inflammatory signaling molecule, we will present and discuss several hypotheses regarding potential mechanisms by which PRG4 may be able to regulate inflammation. If future studies can demonstrate that PRG4 is a potent inflammatory mediator, this will change current paradigms in the musculoskeletal and ophthalmological fields regarding the how the inflammatory microenvironment is regulated in these tissues and potentially others. (shrink)

Intersexuality, particularly in the global South, remains an under‐researched field of study. In my in‐progress doctoral research project, I explore the cultural, social, and medical discourses that influence how key stakeholders such as healthcare providers make decisions about the sex and gender assignment of the intersex child in India. In this paper I interrogate some of these ideas around gender assignment of intersex people in India, paying particular attention to the context of son preference. I am interested in exploring how (...) decisions of gender assignment by medical professionals are guided by ideas of son preference. Focusing on four qualitative, semi‐structured, in‐depth interviews across two cities with medical doctors from different specializations, this paper is a preliminary attempt to examine some of the factors that guide medical professionals in making decisions about gender assignment of intersex children and explore the dynamics of the decision‐making process. Specifically, I explore the factors that inform doctors’ decision‐making and locate these decision‐making processes within the broader socio‐cultural context of India. (shrink)

Universals are properties that are shared by multiple objects. In classical South Asia, Brahmanical thinkers from Vyākaraṇa, Nyāya, Vaiśeṣika, and Mīmāṃsā text traditions were realists about universals, while most Buddhists were nominalists. In this paper, my aim is to reconstruct the early Nyāya-Vaiśeṣika theory of universals, with special emphasis on the arguments of the Nyāya philosopher Uddyotakara (6th century CE) against a Buddhist strand of resemblance nominalism. I show that Uddyotakara's contribution to this debate is twofold. First, he is possibly (...) the first Naiyāyika to adopt a sparse theory of universals, a theory according to which it is necessary to posit only those universals which explain how objects resemble each other in the most fundamental or irreducible respects. On the other hand, he offers a few arguments for realism, which are explicitly motivated by a causal constraint on intentionality. (shrink)

This article analyzes the issue of organizational transparency through the lens of Thomas Aquinas’ ethics. It provides moral justification for current claims about corporate transparency and sheds light on the ethical values and virtues affecting information disclosure decisions. Transparency is conceptualized as an informational mechanism necessary for performing the virtues of truthfulness, justice, and prudence. This article extends the organizational transparency and corporate social responsibility literatures by providing an alternative moral justification grounded in virtue-based theory, which extends our understanding of (...) the information disclosure decisions made by management. (shrink)

Since the 2010s, popular YouTube channels have used derogatory humour at the expense of gendered and racialised others. Founded upon the perception of an influx of ‘wokeness’ in comedy, these videos mock the mythologised ‘unfunny, angry SJW’ and teach the audience to laugh at enemies of the alt-right. Although empirical research has analysed the algorithmic radicalisation of viewers, few have addressed the role of cultural discourses in disseminating alt-right ideology through online media. Here, the right-wing ‘pipeline’ is understood as a (...) tool of radicalisation that weaponises laughter as a tool of regulations and oppression. This paper analyzes the production of derogatory laughter by studying a network of North American content creators including Russell Peters, Lilly Singh, Jordan Peterson, Steven Crowder, and Matt Walsh, using critical tools from psychoanalysis, social psychology, and critical humour studies. Contrary to the alt-right rhetoric that ‘edgy’ humour is harmless, this paper posits derogatory humour as a tool of marginalisation and domination that reinforces white supremacist and cisnormative patriarchal value systems. (shrink)

The Buddha, unlike the Upaniṣadic or Brahmanical way, has avoided the concept of the self, and it seems to be left with limited conceptual possibilities for free will and moral responsibility. Now, the question is, if the self is crucial for free will, then how can free will be conceptualized in the Buddhist ‘no-self’ (anattā) doctrine. Nevertheless, the Buddha accepts a dynamic notion of cetanā (intention/volition), and it explicitly implies that he rejects the ultimate or absolute freedom of the will, (...) but not the minimal power of free will. It seems that the Buddha’s view shifts from agent causation (independent ownership) to a causal sequence of impersonal processes (psychophysical factors). This paper claims to shed clarity on ‘whether free will is viable in the context of the anattāvāda in Buddhism.’ It mainly studies the secondary sources (even though it has also discussed the primary sources) and their interpretations of freedom of the will and how it further does argue for a compatibility approach of free will in Buddhist thought. (shrink)

New York based Families For Freedom is among a handful of organizations that directly organize deportees and their families. Analyzing the organization’s resignification of criminalized men of color as caregivers, I argue that current deportation policies and practices reorganize care work and kinship while tying gender and sexuality to national belonging. These policies and practices severely compromise the ability of migrant communities to socially reproduce themselves. Furthermore, the convergence of criminalization and immigration enforcement renders the kinship ties of deportable men (...) illegible, and justifies their separation from their loved ones. Since FFF publicly supports men with criminal convictions, it reveals that its members become targets of deportation precisely because they do not and cannot conform to heteronormative prescriptions. (shrink)

Within the climate justice debate, the ‘beneficiary pays’ principle holds that those who benefit from greenhouse emissions associated with industrialization ought to pay for the costs of mitigating and adapting to their adverse effects. This principle constitutes a claim of inter-generational justice, and it is widely believed that the non-identity problem raises serious difficulties for any such claim. After briefly sketching the rationale behind ‘beneficiary pays,’ this paper offers a new way of understanding the claim that persons in developed societies (...) have benefited from industrialization. It argues that when we think of the claim in this new way, it evades the non-identity problem entirely. Some objections to this approach are then considered and rebutted. The paper concludes by comparing the present, relatively modest solution to the nonidentity problem with a much more ambitious attempt from the recent literature. (shrink)

Recent work suggests that DNA replication origins are regulated by the number of multiple mini‐chromosome maintenance (MCM) complexes loaded. Origins are defined by the loading of MCM – the replicative helicase which initiates DNA replication and replication kinetics determined by origin's location and firing times. However, activation of MCM is heterogeneous; different origins firing at different times in different cells. Also, more MCMs are loaded in G1 than are used in S phase. These aspects of MCM biology are explained by (...) the observation that multiple MCMs are loaded at origins. Having more MCMs at early origins makes them more likely to fire, effecting differences in origin efficiency that define replication timing. Nonetheless, multiple MCM loading raises new questions, such as how they are loaded, where these MCMs reside at origins, and how their presence affects replication timing. In this review, we address these questions and discuss future avenues of research. (shrink)

Human development can be seen as the process of giving more effective expression to human values. Modern business philosophy has a certain viewpoint or perspective on human potential based on the secular humanistic values of the west and the scientific theories on the nature of man and his evolution. We are bound to welcome the New Paradigm in Business because it opens the path for a decisive step forward in evolution from an authoritarian, mechanistic, Taylorian era to a freer and (...) a more humanistic ethos in business. (shrink)

The United States has the fastest growing prison population in the world, and elevated incarceration rates, substance use, and human immunodeficiency virus (HIV) prevalence are fueling each other. Yet without a national guideline mandated for HIV care within the prison system, standards for state and federal prisons vary greatly.

Echoing bell hooks’s discussions on “black rage,” this article explores the politics of “Dalit rage” by juxtaposing some instances of projections of Dalits as an “angry,” “illiberal,” and “intolerant” constituency with examples of anger from Dalit literature. While these projections in “mainstream” media and caste Hindu–dominated civil society narratives often represent them as engulfed in the emotive states marked by anger, intolerance, and impatience, the instances from Dalit literature archive a “Dalit rage” that demands to be dissociated from the Nietzschean (...) category of ressentiment. Through B. R. Ambedkar’s readings of Nietzsche in Philosophy of Hinduism and Nietzsche’s readings of Manu’s Manavadharmashastra in Twilight of the Idols, this article draws a fine line of differentiation between Nietzsche’s contempt for ressentiment and Manu’s disdain for anger. “Dalit rage” occupies a distinctly different thymotic space and articulates a Dalit predicament that exploits rage as a marker of protest, resistance, and caste-ridden social conflicts. This article shows why we cannot bracket Nietzsche’s contempt for ressentiment with Manu’s demands of the sudras (and, in extension, other “lower castes”/Dalits) to be “meek” by exploring Manu’s perpetuation and legitimization of the varna order through a “morality of breeding” and Nietzsche’s more wholesale rejection of morality as he deems it a pia fraus (moral fraud). Thus this “Dalit rage” offers us a repository of the limits of a liberal democracy and enables an Ambedkarite reading of Nietzsche whose project of constructing ubermensch is markedly different from Manu’s “morality of taming” through a “morality of breeding.”. (shrink)

This chapter is about a classical Indian debate about the Independent Check Thesis, the thesis that, if an agent is to rationally believe (or judge) that she knows that p, she must rely on some source of information that provides her independent evidence about the truth or reliability of her belief (or judgement) that p. While some Buddhists and Nyāya philosophers defended this thesis, the Bhāṭṭa Mīmāṃsakas rejected it. Here, I reconstruct the Bhāṭṭa Mīmāṃsakas’ arguments against the Independent Check Thesis. (...) I show that these arguments reveal a tension between this thesis and a plausible principle that connects knowledge and action. (shrink)

It is widely supposed that evolutionary debunking arguments against morality constitute a type of epistemological objection to our moral beliefs. In particular, the debunking force of such arguments is not supposed to depend on the metaphysical claim that moral facts do not exist. In this paper I argue that this standard epistemological construal of EDAs is highly misleading, if not mistaken. Specifically, I argue that the most widely discussed EDAs all make key and controversial metaphysical claims about the nature of (...) morality or the possibility of moral truth that belie their apparently epistemological character. I show that the debunking force of these EDAs derives largely from metaphysical claims about morality and their implications for the possibility of moral reduction, rather than from epistemological worries associated with the existence of an causal/non-moral explanation of our moral judgments. The paper briefly concludes with a dilemma that I believe confronts all EDAs such as those discussed in this paper: either such arguments are unsound, or else they prove too much, debunking our knowledge of science and the external world, as well as morality. (shrink)